Online resume
and personal web presence.
My experimental lab at SISSA is moving soon to UNIMORE.
Views and opinions expressed here belong solely to the author.
Bio sketch
I am Principal Investigator and Associate Professor of Bioengineering at the Univ. of Modena and Reggio Emilia (Italy). I retain a small and temporary appointment as a Professor of Physiology at SISSA.
Download here my full CV and publications list. Scroll down for a brief biography, or jump straight to one of the sections of my online resume by the navigation bar on your left.
I was born in Genova (Italy) in 1974 and got a (scientific) high-school diploma in 1992. I graduated summa cum laude in Electronic Engineering in 1997 at the Univ. of Genova (Italy), specialising in Biomedical Engineering. In 2001 I moved abroad, after completing a PhD in Bioengineering with a thesis in Computational Neuroscience under the supervision of Prof. Dr. M. Grattarola.
I was awarded with a “long-term fellowship” by Human Frontiers Science Program Organization, to pursue postdoctoral training in experimental Electrophysiology and Neurobiology at the Dept. of Physiology of the Faculty of Medicine of the University of Bern (Switzerland). There, I worked with Prof. Dr. H.R. Luescher and Prof. Dr. S. Fusi.
In 2005, I joined the experimental lab of Prof. Dr. H. Markram as a junior group leader at the Brain Mind Institute of the Swiss Federal Institute of Technology of Lausanne (EPFL).
In 2008, I joined as a “tenure-track” Assistant Professor of Neuroscience the the Dept. of Biomedical Sciences of the Univ. of Antwerp (Belgium). I was appointed as the successor of Prof. Dr. E. De Schutter, and during the following 11 years, I performed and directed interdisciplinary research in experimental Neurobiology, Neuroengineering, and Computational Neuroscience, heading the Lab for Theoretical Neurobiology and Neuroengineering.
From 2013 to 2015, I also held a 20% visiting appointment at the Neuroelectronics Flanders Institute of IMEC, Leuven (Belgium).
In Antwerp, I was tenured in 2012, promoted to Associate Professor in 2013, and to Full Professor in 2016. During the same years, I also had visiting appointments at the Dept. of Computer Science of the Univ. of Sheffield (UK) and at the Brain Mind Institute of the EPFL (Switzerland).
In 2019, I left Belgium to join as a Professor of Physiology the International School of Advanced Studies (SISSA) of Trieste, Italy, moving my team at SISSA’s Neuroscience Area, and starting the Neuronal Dynamics Laboratory.
In 2024, I was appointed Professor of Bioengineering by the Univ. of Modena and Reggio Emilia, joining its Dept. of Biomedical, Metabolic and Neural Sciences. In Modena, I joined the newly launched Master in Biomedical Engineering, contributing with my vision on Neural Engineering.
Education and Degrees
I have been trained to “speak the language” of engineers, physicists, physiologists, and neuroscientists, and had the opportunity of an international academic career in a variety of institutions and faculties.
- 2017 - 2034 Italian Academic Habilitation, “1 Fascia” (Full Prof.): Bioengineering (09/G2)
- 2023 - 2034 Italian Academic Habilitation, “1 Fascia” (Full Prof.): Physiology (05/D1)
- 2017 - 2023 Italian Academic Habilitation, “2 Fascia” (Assoc. Prof.): Bioengineering (09/G2)
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2017 - 2023 Italian Academic Habilitation, “2 Fascia” (Assoc. Prof.): Physiology (05/D1)
- 1997 - 2001 Polytechnic of Milan, (I): PhD in Bioengineering
- 1998 - 1998 Univ. of Genova, (I): Habilitation as Chartered Engineer (score 110/110)
- 1992 - 1997 Univ. of Genova, (I): Electronic Engineering Laurea, MEng eq., 110/110 cum laude
- 1987 - 1992 Liceo M. Champagnat, Genova: Diploma di Maturità Scientifica (score: 57/60)
Research Focus
By Dec 2023, according to Google Scholar, my h-index is 32 (27 according to Scopus), and my 86 publications received over 5’400 citations.
As a Bioengineer and Physiologist, with extensive cross disciplinary experience in Neuroscience, my research ultimately aims at the understanding, repairing, replacing, and enhancing of the electrical properties of neural systems. I study the biophysics and electrophysiology of individual nerve cells as well as of microcircuits and networks, which compose the mammalian cortex. Besides moving towards our fundamental understading of the brain, I search for the most appropriate (simplified) levels of description of the complex operations of cells and microcircuit. This knowledge will be instrumental for interfacing living neural tissue and artificial systems, combined with exploiting recent progresses in nanotechnologies.
More specifically, my multidisciplinary research in Neuroscience, Neuroengineering, nervous system modeling, and high-tech cell electrophysiology focuses on two major directions:
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studying mechanisms of brain (dys)functions, laying the foundations for the study and the treatment of pathologies at the molecular, cellular, and network levels;
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exploitating technologies, experimental methods, and quantitative approaches - common in physics and engineering - to study, repair, recreate, or increase the functions of the brain.
Within the landscape defined by these directions, over the past 15 years (as I have gained full academic independence) my research has focused at the overlap among 1) cell electrophysiology, 2) computational neuroscience and 3 ) Neurotechnology.
I have been intriguired by the examination, under highly-controlled conditions, of the multiplicity of time scales of neuronal excitability, and have chosen a class of cortical neurons for my investigation. I pioneered an experimental characterisation of neuronal excitability that is pivotal for quantifying the dynamical response properties of neuronal ensembles, self-sustained oscillations, and downstream propagation of correlated activity. Taclking this research questions required the design of innovative and unconventional experimental protocols, directly inspired by statistical physics, dynamical system theory, and by the theory of stochastic processes.
I have been also inspired by the possibilities offered by “reduced” (in vitro) biological preparations, such as dissociated neuronal circuits and brain tissue slices, especially obtained from therapeutic resective neurosurgery in humans. We live perhaps in a time of very high expectations in predictive power of large-scale computational approaches for tackling whole-brain functions. I believe that first validating methods, theories, and simulations in a reduced context with high physico-chemical control and comprhensive experimental access, is a priority.
With talented colleagues, I first discovered quantitative differences in the physiology of human cortical neurons. This further convinced me of the value of reduced preparations and precise biophysical experiments for constraining theories and explanatory principles, which are unfortunately scarce in today’s Neurosciences. Before stating how the brain can be described, simulated, and modeled with current tools and models, we must offer an in vitro validation capable - as has happened - of revealing unexpected results and differences.
Finally, with regards to nanotechnology and microelectronics, I have had the unique opportunity to participate in the study of properties and consequences of coupling biological neuronal networks to nanomaterials. This is the key to build sophisticated investigation tools and lay the foundations to design, microfabricate and employ new “intelligent” interfaces between neurons and conventional electrodes, aiming for neuroprostheses and future brain pacemakers.
I conclude summarising below a selection of major discoveries I contributed to thanks to excellent collaborators and students:
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I discovered a new (functional) class of pyramidal neurons of the rat prefrontal cortex (J. Neurosci., ‘07) that show unique steady-state response properties, brought to light by stochastic stimulation inspired by extended mean field theory;
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I was the first to measure the “bandwidth” of the dynamic response properties of cortical neurons (Cereb. Cortex, ‘08), extending theoretical predictions;
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In the same context, I was the first to describe quantitative differences in the information processing “speed” of human cortical neurons compared to rodents (PLoS Biol, 2014);
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I was also the first to reveal the impact on neuronal excitability of realistic in vitro stimulation based on conductances and not synaptic currents (Eur J of Neuroscience);
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I discovered and experimentally described previously overlooked heterogeneous correlation transfer properties of cortical interneurons (J Neuroscience);
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I described a “bug” (or “opportunity”) of Optogenetic stimulation, applied in recurrent neuronal networks (Sci. Reports), using in vitro experimental and modeling approaches;
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I proposed a fast and accurate numerical method for simulating channel “noise”. (PLoS Comp Biology, 2011), filling a 15-year “gap” in the literature.
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I developed a theory for the emergence of (a)symmetric synaptic connections in heterogeneous areas of the cortex (PLoS ONE, 2013), based on existing explanatory principles;
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I helped demonstrate for the first time that human pyramidal neurons (derived from cells stem) are reintegrated, after in vivo grafting , into functional circuits (Neuron, 2013);
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I contributed to the exploration of in vitro models of dysfunctional cortical connectivity (Huntington, alfa-sinucleina, Fragile X, ipossia) (Nature 2015; Cereb Cortex; Cell Reports);
Selected Publications
Past Research Experience
- 2022 - 2023 Associate Prof. of Physiology, SISSA (I)
- 2019 - 2022 Assistant Prof. of Physiology, SISSA (I)
- 2016 - 2019 Research-mandate Hoogleraar (Full Prof.), Dept. Biomed. Sci., Univ. Antwerp (B)
- 2008 - 2019 Head of the Theoretical Neurobiology and Neuroengineering lab, Univ. Antwerp (B)
- 2018 - 2018 collaboration of excellence invited Prof. at SISSA, Trieste (I)
- 2008 – 2018 External collaborator at the Brain Mind Institute, EPFL, Lausanne (CH)
- 2010 – 2018 Visiting academic at the Dept. of Computer Science, University of Sheffield (UK)
- 2016 - 2016 4-month scientific visit in a SME (QWANE Biosciences, CH)
- 2013 – 2016 Visiting Scientist at NERF (Flanders Neuroelectronic Institute)
- 2013 – 2016 Scientific Coordinator, EC-FP7 FET-OPEN Project BRAINLEAP
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2011 – 2015 Scientific Coordinator, EC-FP7 Marie-Curie Initial Training Network NAMASEN
- 2013 – 2015 Research-mandate Hoofddocent (Associate Prof.), Dept. Biomed. Sci., U. Antwerp (B)
- 2011 - 2011 Tenured appointment, Univ. Antwerp (B)
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2008 – 2010 Tenure-track research-mand. Docent (Assist. Prof.); Dept. Biomed. Sci., U. Antwerp (B)
- 2005 – 2008 Junior group leader (with H. Markram), Brain Mind Institute, EPFL (CH)
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2001 – 2005 HFSPO postdoc (with HR. Lüscher), Inst. of Physiology, Univ. of Bern (CH)
- 1999 - 1999 Visiting PhD student (with G. Le Masson), Inst. de Neurosci. F. Magendie, Bordeaux (F)
- 1999 - 1999 Visiting PhD student (with A. Nistri and E. Cherubini), Biophysics Sector, SISSA, Trieste (Italy).
- 1997 – 1998 Visiting PhD student (with R.J. Douglas and K. Martin), Institute of Neuroinf., ETH, Zürich (CH)
- 1997 – 2001 PhD student (with M. Grattarola), Dept. Biophys. & Electr. Engineering, Univ. of Genova (I)
- 1995 – 1996 Undergraduate student (with I. Martin), Advanced Biotechnology Center, Genova (I)
Honors and awards
- 2009 Ghent, Belgium: Best poster Award, sponsored by Cochlear
- 2008 Univ. La Sapienza, Rome, Italy: Science Award to Young Investigators
- 2003 Swiss Physiological Society, Asher-Hess Young Investigator Award (2nd prize)
- 2001 – 2004 Human Frontier Science Program, France, Long-term Fellowship
- 1997 Dignity of Publication and Highest Honors for MEng Thesis
- 2004 Italian Society for Neurosci., Travel grant for attending the FENS Congress
- 1997 – 1999 Univ. of Genova, Travel grants for PhD training activities
- 1998 Polytechnic of Milan, Grad School admission natl. exam, 1st rank (score: 114/120)
- 1997 Univ. of Genova (I), Grad School admission natl. exam, 1st rank (score:114/120)
Invited talks
Over the years, I gave over 109 invited talks (more than 70% abroad).
- 2024 2024 Neuronics Conference, València (ES)
- 2023 CIMaINa - Dept. of Physics, University of Milan (I)
- 2023 European Solid-state Devices and Circuits Conference, Lisbon (P)
- 2023 Human Slices Workshop, Charité-Universitätsmedizin, Freie Univ. Berlin (D)
- 2023 Brain-Inspired Computing, Univ. Modena (I)
- 2023 Center for Complexity & Biosystems, Dept. Physics, Univ. Milan (online)
- 2022 Neurosurgery, Head-Neck and NeuroScience Dept., Univ. Hospital Udine (I)
- 2021 Brain-Inspired Computing: From Neuroscience to AI, Univ. Modena (I)
- 2021 NeuroWire Virtual Club (neurowire.ca) at Laval University, Canada (online)
- 2021 Neural circuit complexity. Lake Como School of Advanced Studies (I)
- 2019 Dipartimento di Bioingegneria, Politecnico di Milano (I)
- 2019 Consiglio Nazionale delle Ricerche, Palermo (I)
- 2019 Department of Computer Science, The University of Sheffield (UK)
- 2019 Spring School Faculty, European Institute for Theoretical Neuroscience, Paris (F)
- 2019 International School of Advanced Studies, SISSA (Italia)
- 2019 Workshop, European Institute for Theoretical Neuroscience, Paris (F)
- 2018 Department of Computer Science, University of Nottingham (UK)
- 2018 University of Verona (I)
- 2018 OCNC: OIST Computational Neuroscience Course, OIST, Okinawa (Japan)
- 2018 ICM Institut du Cerveau et de la Moelle épinière, Paris (F)
- 2018 “Neurotechnologies and computational methods” school, Univ. Genova (I)
- 2018 I3S Instituto de Investigação e Inovação em Saúde, Porto (Portugal)
- 2018 Lecture on “Physics of the Brain”, University of Ghent (Be)
- 2018 Research Club, UZA, University Hospital of Antwerp (Be)
- 2017 Department of Life Sciences, University of Trieste (I)
- 2017 ICANN 2017 - 26th Intl. Conf. on Artificial Neural Net., Alghero (I), keynote
- 2017 FisMat 2017, Italian Natl. Conf. on the Physics of Matter, ICTP, Trieste (I)
- 2017 OCNS Intl. Comp Neurosci Conf., Antwerp (B)
- 2017 VII Neuron Technology Summer School, SISSA, Trieste (I)
- 2017 WiBrain Conference, ICM Institute for Brain and Spinal Cord, Paris (F)
- 2017 The Cognitive Neuromorphic Engineering Workshop, Capocaccia (I)
- 2017 Epilepsy Genetic Network Meeting, Edegem (B)
- 2016 NeuroMath: Theoretical & Computational Neuroscience, Cortona (I)
- 2016 Interuniversity Initiative on Optogenetics, KULeuven, Leuven (B)
- 2016 Laboratory of Computational Neuroscience, BMI, EPFL Lausanne (CH)
- 2016 Opto- & other genetic approaches in systems neuroscience, Nijmegen (NL)
- 2016 University of Padua (I), Neurotechniques School
- 2015 2nd Belgian Neuroinformatics Congress, Leuven (B)
- 2015 SfN satellite symposium, Chicago (US)
- 2015 Neurosurgery. Clinical research at the University Hospital Antwerp (B).
- 2015 37th Annual Conference of the IEEE Eng. in Medicine & Biology Soc., Milan (I)
- 2015 “Spike initiation: models and experiments” CNS2015 Workshop, Prague (CZ)
- 2015 B-Debate: “A Dialogue with the Cerebral Cortex: Function & Interfacing” (Spain)
- 2015 University of Padua (I), Neurotechniques School
- 2015 Donders Centre for Neuroscience, Nijmegen (The Netherlands)
- 2015 BENEFRI Neuroscience Workshop, Univ. Bern (CH)
- 2015 NETT Winter School on Neural Engineering, Imperial College London (UK)
- 2015 University of Padua (I), Neurotechniques School
- 2014 BRAIN-FETs: Clustering Workshop on Future Emerging Neurotechnologies (I)
- 2014 Neuroinformatics 2014 Workshop, Leiden (The Netherlands)
- 2014 Laboratory of Computational Neuroscience, BMI, EPFL Lausanne (CH)
- 2014 NERF Neurotechnology Symposium, Leuven (B)
- 2013 Dept. Bioengineering, Imperial College London (UK)
- 2013 Congress of the Italian Society for Neuroscience (I)
- 2013 NAMASEN Marie Curie Training Network Workshop, University of Sheffield (UK)
- 2013 Russian Acad. Sci. - Inst. of Physics: Topical problems of Biophotonics (Russia)
- 2013 “Network Neurosciences: structure and dynamics” CNS2013 Workshop (F)
- 2013 NETT Marie Curie Training Network Workshop, University of Nottingham (UK)
- 2013 “Guru Lecture series” in Neuroscience, The University of Sheffield (UK)
- 2013 Department of Computer Science, The University of Sheffield (UK)
- 2013 Institute of Neuroinformatics Colloquium, ETHZ/University of Zürich (CH)
- 2012 60 Years of the Hodgkin-Huxley Model, Trinity College, Cambridge UK, speaker
- 2012 European School of Neuroengineering “Massimo Grattarola”, Genova (I), faculty
- 2012 Belgian Physical Society Congress, Brussels (B)
- 2012 VIB - KULeuven, Leuven (B)
- 2011 Univ. Bruxelles, Leuven (B)
- 2011 IMEC, invited speaker, Leuven (B)
- 2011 Polish Neuroscience Society, Lodz, (Poland)
- 2011 Max Planck Institute for Biol. Cybernetics, Tübingen (Germany)
- 2011 CNRS-Laboratory of Neurophysics and Physiology in Paris (F)
- 2011 University of Sheffield (UK), Dept. Computer Science
- 2011 University of Padua (I), Neurotechniques School
- 2011 The Israeli Institute of Technology (Technion), Haifa (Israel)
- 2010 Session Opening Lecture, NanoMed 2010, Berlin (Germany)
- 2010 Keynote speaker, Intel European Res. & Innovation Conference, Dublin (Ireland)
- 2010 European Brain Research Institute, Rome (I)
- 2010 Anniversary lecture - 20 years IMO-IMOMEC , Univ. Hasselt (B)
- 2010 University of Mons, Materia Nova, Mons (B)
- 2009 7th fall course on Comp. Neurosci. ,Max-Planck-Institut, Göttingen (D)
- 2009 EuroNanoForum 2009, Prague (Czech Republic)
- 2009 School on Neuroelectronic Hybrid Systems, Inst. for Advanced Studies, HUJI (Israel)
- 2009 Univ. of Liege, Centre de Recherches du Cyclotron, Liege (B)
- 2009 Univ. of Leuven, Dept. of Neuroscience, Leuven (B)
- 2009 Johnson & Johnson (Janssen Pharmaceutica), CNS Discovery
- 2008 Department of Physics, University of Antwerp, Antwerp (B)
- 2008 INCF National Node Workshop (Varenna, Italy)
- 2008 Workshop on Bioelectronics, IMEC, Leuven (B)
- 2008 Computation in Cortical Circuits, Monte Verita’, Ascona (CH)
- 2008 Italian Institute of Technology, Genoa (I)
- 2008 Max-Planck-Institut, Göttingen (Germany)
- 2008 “FlandersBio: Neuro Café”, Mechelen (B), keynote
- 2008 Brain Research Institute, University of Zürich (Swizterland)
- 2008 Faculty of Medicine and Biology, University of Lausanne (CH)
- 2007 Institute of Neuroinformatics Colloquium, ETHZ/University of Zürich (CH)
- 2007 Institute of Molecular Biology and Biotechnology, Heraklion (Crete)
- 2006 European Brain Research Institute, Rome (I)
- 2006 Okinawa Computational Neuroscience Course, Okinawa (Japan), invited tutor
- 2006 European School of Neuro-IT and Neuroengineering Genova (I)
- 2005 Congress of the Italian Society for Neurosciences Ischia (I)
- 2005 QinetiQ UK Workshop “Demo & analysis of learning neuronal networks”
- 2005 Complex Systems Unit, Dept. Tech. & Health, Italian Natl Inst Health, Rome (I)
- 2004 Laboratory of Computational Neuroscience, BMI, EPFL Lausanne (CH)
- 2004 Inst. für Biologie III, Albert-Ludwigs Univ., Freiburg (D)
- 2003 Neural Microcircuitry Laboratory, BMI, EPFL Lausanne (CH)
- 2001 – 2002 NeuroEngineering Workshop & Advanced School, Univ. Genova (I)
- 2001 Symposium at the Congress of Italian Society for Neurosciences, Torino (I)
- 2000 Dept. Communication, Computer and System Sciences, Univ. of Genova (I)
Funding record
By 2023, I have attracted 8.1 M€ as research grants (1.9 M€ of which, during 2019-2023).
- 2022 - 2025 MIUR-PNRR Infrastructures, eBRAINS-Italy, PI
- 2022 - 2026 EC-HE, EIC-Pathfinder - CROSSBRAIN Project, PI
- 2020 - 2023 EC-Flagship, SGA3 - Human Brain Project, PI
- 2020 - 2024 EC-H2020, FET - IN-FET Project, PI and Coordinator
- 2020 - 2023 EC-Flagship, SGA3 - Human Brain Project, P.I.
- 2020 - 2023 EC-H2020 FET-OPEN Grant, P.I. and coordinator
- 2018 - 2020 EC-Flagship, SGA2 - Human Brain Project, P.I.
- 2017 - 2019 Grant G.0F15.17.N, Research Foundation Flanders (FWO), P.I.
- 2016 - 2018 EC-Flagship, SGA1 - Human Brain Project, P.I.
- 2015 - 2015 Congress Organisation grant, Research Foundation Flanders (FWO)
- 2015 - 2015 Congress Organisation grant, Univ. Antwerp
- 2012 – 2017 Belgian Science Policy Office, P.I.
- 2013 – 2016 EC-FP7 ICT FET-OPEN Strep Grant, P.I. and coordinator
- 2013 - 2013 Development Support Grant, Univ. Antwerp, co-P.I.
- 2012 - 2012 PhD salary grant, Univ. Antwerp, P.I.
- 2012 – 2016 Grant G.0888.12.N, Research Foundation Flanders (FWO), P.I.
- 2012 – 2015 EC-FP7 ICT FET-OPEN Strep Grant, P.I.
- 2012 – 2015 EC-FP7 NMP Strep Grant, P.I.
- 2011 – 2015 EC-FP7 Marie Curie Initial Training Network, P.I. and coordinator
- 2011 – 2015 Grant G.0136.11N, Research Foundation Flanders (FWO), co-P.I.
- 2011 - 2011 Development Support Grant, Univ. Antwerp, P.I.
- 2010 – 2013 EC FP-7 “Matera+” / IWT, PI
- 2010 – 2012 “e-GAP2” grant, UK Royal Society, co-P.I.
- 2010 - 2010 Congress Organization grant, Univ. Antwerp, P.I.
- 2009 – 2013 New Research Initiatives grant (BOF/NOI), Univ. Antwerp, P.I.
- 2009 – 2011 Grant G.0836.09, Research Foundation Flanders (FWO)
- 2009 – 2010 Congress Organization grant, “Centro Stefano Franscini”, co-P.I.
- 2008 – 2011 Professorship Mandate, Foundation “Franqui Stichting”, P.I.
- 2008 – 2011 Competitive Start-up grant, Univ. Antwerp, P.I.
- 2008 – 2011 “Stoicescu research grant”, EPFL, co-P.I.
- 2006 – 2009 Grant “NEURONANO”, EC FP-6, co-P.I.
- 2005 – 2008 Research grant, Swiss National Science Foundation, co-P.I.
- 2001 – 2004 Long-term Fellowship award, Human Frontier Science Program, France, P.I.
- 2000 – 2001 Research grant for “Young Researchers”, Univ. of Genova, P.I.